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Effect of long term feeding of high fat diets on growth, plasma and tissue lipids in rats.

Narasimhamurthy, K. and Raina, P. L. and Hariharan, K. (1997) Effect of long term feeding of high fat diets on growth, plasma and tissue lipids in rats. Journal of Food Science and Technology, 34 (4). 303-310; 48 ref.. ISSN 0022-1155

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Male CFT-Wistar rats (n=8 per group) were fed on standard diets containing 5 or 20% peanut [groundnut] oil (PNO), sesame oil (SO) or coconut oil (CNO) for 18 weeks. The growth rates of rats fed on 20% fat diets were higher than those fed on 5% fat diets. No significant differences were observed in the total plasma cholesterol (C) levels in any of the groups, but significantly low levels of HDL-C and high levels of LDL-C + VLDL-C were observed in CNO groups. Liver C and phospholipid levels were significantly lower in CNO and SO groups. Plasma fatty acid analysis indicated higher levels of decanoic, palmitic and stearic acids in CNO groups compared to others. Analysis of erythrocyte fatty acids indicated high levels of arachidonic acid in CNO groups, despite low levels of linoleic acid in CNO. The arachidonic acid levels were higher in erythrocytes and were independent of the supply of linoleate. Adipose tissue fatty acid analysis indicated low levels of linoleate and high levels of saturated fatty acids in CNO group as compared to other groups. The ratios such as oleic/linoleic, oleic/stearic and linoleic/arachidonic acid were normal, indicating the type of fat consumed. It is concluded that feeding higher levels of CNO can lead to an increase in the saturated fatty acids, LDL and VLDL, as compared to SO- and PNO-fed rats.

Item Type: Article
Uncontrolled Keywords: saturated-fatty-acids; linoleic-acid; arachidonic-acid; fatty-acids; phospholipids-; Liver-; lipoproteins-; fats-; intake-; growth-; blood-lipids; groundnut-oil; sesame-oil; coconut-oil; cholesterol-; high-density-lipoprotein; low-density-lipoprotein; very-low-density-lipoprotein; decanoic-acid; palmitic-acid; stearic-acid; erythrocytes-; adipose-tissue; oleic-acid; polyenoic-fatty-acids; monoenoic-fatty-acids
Subjects: 500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 11 Lipid Biochemistry
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 16 Jun 2017 08:36
Last Modified: 28 Sep 2018 10:20
URI: http://ir.cftri.com/id/eprint/8616

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