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Induction of glutathione S-transferase by fumigants in larvae of the khapra beetle, Trogoderma granarium (E.).

Shivanandappa, T. and Rajendran, S. (1987) Induction of glutathione S-transferase by fumigants in larvae of the khapra beetle, Trogoderma granarium (E.). Pesticide Biochemistry and Physiology, 28 (1). 121-126; 26 ref..

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The effect of fumigants on glutathione and glutathione transferase in larvae of Trogoderma granarium was studied by fumigating for 1, 3 and 5 h with a dose causing 100% mortality after exposure for 24 h. Glutathione and glutathione transferase were assayed in the cytosol at 1, 3 and 5 h of exposure. Time-dependent depletion of glutathione was seen for all fumigants except carbon tetrachloride and phosphine. The depletion was maximum (60-70%) in the cases of methyl bromide, methyl iodide and acrylonitrile, and least (20-30%) in the cases of ethylene dibromide and ethylene oxide. The order of glutathione depletion by various fumigants after exposure for 5 h was methyl iodide > methyl bromide = acrylonitrile > ethylene dichloride > ethylene oxide > ethylene dibromide. Glutathione transferase was induced by all fumigants except ethylene dibromide, methyl bromide being more potent than methyl iodide. The enzyme induction ranged from 186% by acrylonitrile to 40% by carbon tetrachloride. Mortality above 10% correlated well with the degree of glutathione depletion (r = 0.729) whereas the latter did not correlate with the transferase induction.

Item Type: Article
Uncontrolled Keywords: Glutathione-transferase; Enzymes-; Stored-products-pests; Insecticides-; fumigants-; effects-; Carbon-tetrachloride; Phosphine-; Methyl-bromide; Ethylene-dichloride; Ethylene-oxide; pesticides-; animal-physiology; agricultural-entomology
Subjects: 600 Technology > 03 Agriculture > 05 Insect/Pest Control
Divisions: Food Protectants and Infestation Control
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 24 Mar 2011 11:39
Last Modified: 17 Oct 2018 06:50
URI: http://ir.cftri.com/id/eprint/8444

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