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Influence of capsaicin, curcumin and ferulic acid in rats fed high fat diets.

Srinivasan, M. R. and Sathyanarayana, M. N. (1987) Influence of capsaicin, curcumin and ferulic acid in rats fed high fat diets. Journal of Biosciences, 12 (2). pp. 143-152.

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Abstract

Three compounds capsaicin, curcumin and ferulic acid showing hypolipidemic activity have been tested in adult Wistar rats fed high fat diets. Capsaicin (0·20 mg%) fed to female rats along with a 30% saturated fat diet lowered the rate of weight gain, liver and serum triglycerides. In male rats it lowered only the liver and serum total and very low density and low density lipoprotein triglycerides whether fed continuously for 13 or 8 weeks after interchanging the control and test diets from the 5th week onwards. Capsaicin fed to female rats in 30% mixed fat diet increased the rate of weight gain, lowered liver and serum triglycerides, lowered adipose tissue lipoprotein lipase, elevated the hormone sensitive lipase and serum free fatty acids. Capsaicin in 30% saturated fat diet lowered both the enzyme activities to a much lesser extent. Curcumin and ferulic acid (both at 25 mg%) in 30% saturated fat diet tended to lower the rate of weight gain, liver total lipids and serum triglycerides. It is of significance that a common dietary compound 'capsaicin' in the range of human intake triggers lipid lowering action in rats fed high fat diets.

Item Type: Article
Uncontrolled Keywords: Capsaicin; curcumin; ferulic acid; lipids; lipoprotein lipase; hormone sensitive lipase.
Subjects: 500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 11 Lipid Biochemistry
600 Technology > 08 Food technology > 30 Spices/Condiments
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 12 Mar 2018 08:34
Last Modified: 12 Mar 2018 08:34
URI: http://ir.cftri.com/id/eprint/4409

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