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Biochemical systems involving 'single carbon' transfers.

Dalal, F. R. and Sreenivasan, A. (1960) Biochemical systems involving 'single carbon' transfers. Proceedings of the National Institute of Science India, 26A (1). pp. 232-249.

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Known information of l-earbon transfer reactions and the involvement of PGA and vitamin B12 in these transfers can be summed up as follows: 1. In the synthesis of several protoplasmic constituents, one of the basic building units has been recognized as the l-carbon unit, expressed as 'methyl', 'hydroxymethyl' and 'formyl', depending on the oxidation level. 2. These units are known to be derived from simple carbon compounds including formate, formaldehyde, serine, glycine, acetone, methanol, etc. 3. Reactions involving the transfer of 'hydroxymethyl' or 'formyl' have been characterized as requiring THPGA as a carrier. 4. Although vitamin B12 shows a potentiating influence, its exact significance in the l-carbon metabolism is still far from clear. Diverse other metabolic processes directly or indirectly influenced by the two vitamins and involving l-C transfers are as yet not precisely defined. Information regarding changes in oxidation level of the l-carbon unit, and its ultimate liberation as carbon dioxide, is also meagre. The tempo of recent research, directed in many ways, is however certain to unfold these patterns ere long.

Item Type: Article
Uncontrolled Keywords: vitamin B12, l-carbon metabolism
Subjects: 600 Technology > 01 Medical sciences > 12 Metabolism
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 23 Jul 2012 07:08
Last Modified: 23 Jul 2012 07:08
URI: http://ir.cftri.com/id/eprint/3177

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