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Supplementation and delivery of n-3 fatty acids through spray-dried milk reduce serum and liver lipids in rats.

Ramaprasad, T. R. and Baskaran, V. and Sambaiah, K. and Lokesh, B. R. (2004) Supplementation and delivery of n-3 fatty acids through spray-dried milk reduce serum and liver lipids in rats. Lipids, 39 (7). pp. 627-32. ISSN 0024-4201

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Indian diets comprising staples such as cereals, millets, and pulses provide 4.8 energy % from linoleic acid (18:2n-6) but fail to deliver adequate amounts of n-3 FA. Consumption of long-chain n-3 PUFA such as EPA (20:5n-3) and DHA (22:6n-3) is restricted to those who consume fish. The majority of the Indian population, however, are vegetarians needing additional dietary sources of n-3 PUFA. The present work was designed to use n-3 FA-enriched spray-dried milk powder to provide n-3 FA. Whole milk was supplemented with linseed oil to provide alpha-linolenic acid (LNA, 18:3n-3), with fish oil to provide EPA and DHA, or with groundnut oil (GNO), which is devoid of n-3 PUFA, and then spray-dried. Male Wistar rats were fed the spray-dried milk formulations for 60 d. The rats given formulations containing n-3 FA showed significant increases (P < 0.001) in the levels of LNA or EPA/DHA in the serum and in tissue lipids as compared with those fed the GNO control formulation. Rats fed formulations containing n-3 FA had 30-35% lower levels of serum total cholesterol and 25-30% lower levels of serum TAG than control animals. Total cholesterol and TAG in the livers of rats fed the formulations containing n-3 FA were lower by 18-30% and 11-18%, respectively, compared with control animals. This study showed that spray-dried milk formulations supplemented with n-3 FA are an effective means of improving dietary n-3 FA intake, which may decrease the risk factors associated with cardiovascular disease.

Item Type: Article
Uncontrolled Keywords: n-3 FA spray-dried milk powder cardiovascular disease
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 17 Fatty Acid Chemistry
Divisions: Dept. of Biochemistry
Lipid Science and Traditional Foods
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 01 Jul 2009 11:25
Last Modified: 16 Jan 2017 12:28
URI: http://ir.cftri.com/id/eprint/2012

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