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Anti-inflammatory potential of probiotic Lactobacillus spp. on carrageenan induced paw edema in Wistar rats.

Ann Catherine, Archer and Muthukumar, S. P. and Prakash, M. Halami (2015) Anti-inflammatory potential of probiotic Lactobacillus spp. on carrageenan induced paw edema in Wistar rats. International Journal of Biological Macromolecules, 81. pp. 530-537. ISSN 0141-8130

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Abstract

The aim of the present study was to evaluate the anti-inflammatory ability of novel indigenous probiotic Lactobacillus fermentum MCC 2759, L. fermentum MCC 2760 and Lactobacillus delbrueckii MCC 2775 in a carrageenan induced acute inflammatory paw edema model. Probiotic cultures were administered to male Wistar rats via oral route. Carrageenan at a concentration of 1% was injected into hind paw of rats 30 min after oral gavage on the 8th day of treatment regimen. Paw thickness (mm), stair climbing activity and motility score were the parameters used to score the inflammatory response. L. fermentum MCC 2759, L. fermentum MCC 2760 and L. delbrueckii MCC 2775 showed significant reduction in paw thickness (P < 0.05) showing percentage inhibition of 15.67%, 14.72% and 14.84%, respectively, 24 h after carrageenan induction. Probiotic treatment also markedly alleviated the stair climbing and motility score. Histological analysis of tissue sections revealed reduction in cellular infiltration of probiotic and drug treatment groups. Adhesion to resected rat intestinal tissue also showed significant adherence capability (>40%) of the probiotic cultures used. Therefore, L. fermentum MCC 2759, L. fermentum MCC 2760 and L. delbrueckii MCC 2775 may be used as potent anti-inflammatory agents with probiotic health benefits.

Item Type: Article
Uncontrolled Keywords: Probiotics Paw edema Lactobacillus spp
Subjects: 600 Technology > 08 Food technology > 29 Microbiological food
Divisions: Dept. of Biochemistry
Food Microbiology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 03 Jun 2019 04:26
Last Modified: 03 Jun 2019 04:26
URI: http://ir.cftri.com/id/eprint/14108

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