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Evaluation of hepatoprotective and antioxidant activity of astaxanthin and astaxanthin esters from microalga-Haematococcus pluvialis.

Ranga Rao, A. and Sarada, R. and Shylaja, M. Dharmesh and Ravishankar, G. A. (2015) Evaluation of hepatoprotective and antioxidant activity of astaxanthin and astaxanthin esters from microalga-Haematococcus pluvialis. Journal of Food Science and Technology, 52 (10). pp. 6703-6710. ISSN 0022-1155

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Abstract

Effect of isolated astaxanthin (ASX) and astaxanthin esters (ASXEs) from green microalga-Haematococcus pluvialis on hepatotoxicity and antioxidant activity against carbon tetrachloride (CCl4) induced toxicity in rats was compared with synthetic astaxanthin (SASX). ASX, ASXEs, and SASX, all dissolved in olive oil, fed to rats with 100 and 250 μg/kg b.w for 14 days. They were evaluated for their hepatoprotective and antioxidant activity by measuring appropriate enzymes. Among the treated groups, the SGPT, SGOT and ALP levels were decreased by 2, 2.4, and 1.5 fold in ASXEs treated group at 250 μg/Kg b.w. when compared to toxin group. Further, antioxidant enzymes catalase, glutathione, superoxide dismutase and lipid peroxidase levelswere estimated in treated groups, their levels were reduced by 30–50 % in the toxin group, however these levels restored by 136.95 and 238.48 % in ASXEs treated group at 250 μg/kg. The lipid peroxidation was restored by 5.2 and 2.8 fold in ASXEs and ASX treated groups at 250 μg/kg. The total protein, albumin and bilirubin contents were decreased in toxin group, whereas normalized in ASXEs treated group. These results indicates that ASX and ASXEs have better hepatoprotection and antioxidant activity, therefore can be used in pharmaceutical and nutraceutical applications and also extended to use as food colorant.

Item Type: Article
Uncontrolled Keywords: H. pluvialis . ASX . ASXEs . CCl4 . Antioxidants . Hepatoprotection . SGPT, SGOT, ALP
Subjects: 500 Natural Sciences and Mathematics > 08 Botanical sciences > 01 Botany > 01 Algae
600 Technology > 08 Food technology > 32 Antioxidants
Divisions: Dept. of Biochemistry
Plant Cell Biotechnology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 08 Jan 2016 05:34
Last Modified: 08 Jan 2016 05:34
URI: http://ir.cftri.com/id/eprint/12053

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