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Evidence of oxidative stress and mitochondrial dysfunctions in the testis of prepubertal diabetic rats

Chandrashekar, K. N. and Dr., Muralidhara (2009) Evidence of oxidative stress and mitochondrial dysfunctions in the testis of prepubertal diabetic rats. International Journal of Impotence Research , 21. pp. 198-206.

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Abstract

Earlier, we have shown the occurrence of oxidative impairments and their progression in the testis of diabetic adult rats. This study investigated the vulnerability of immature testis to oxidative stress and mitochondrial dysfunctions in a prepubertal (PP) diabetic rat model. PP male rats (4/6-weekold) rendered diabetic by an acute dose of streptozotocin were monitored for induction of oxidative stress in testis cytosol/mitochondria. Diabetic rats of both age groups showed severe hyperglycemia, testicular atrophy and marked oxidative damage as evidenced by enhanced generation of reactive oxygen species, hydroperoxide and malondialdehyde levels (4 week46 week). Mitochondrial dysfunctionsmanifested as reduction in the activities of aldehyde dehydrogenase, tricarboxylic acid cycle enzymes, enhanced activities of oxidative phosphorylation enzymes, perturbations in calcium homeostasis and membrane potential. These evidences suggest that an immature testis is vulnerable to oxidative stress under diabetes, which may play a significant role in the development of testicular degeneration, leading to impaired fertility in adulthood.

Item Type: Article
Uncontrolled Keywords: diabetes; prepubertal rats; testis; atrophy; cytosolic/mitochondrial oxidative stress Introduction Diabetes mellitus is becoming a significant healthcare concern worldwide. This metabolic disorder is characterized by insulin resistance and physiological/ biochemical malfunctioning of different metabolic pathways
Subjects: 600 Technology > 01 Medical sciences > 04 Diabetes Mellitus
600 Technology > 01 Medical sciences > 12 Metabolism
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 28 Sep 2010 04:42
Last Modified: 09 May 2012 05:09
URI: http://ir.cftri.com/id/eprint/9719

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