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Neuroprotective effect of Decalepis hamiltonii roots against ethanol-induced oxidative stress

Anup, Srivastava and Shivanandappa, T. (2010) Neuroprotective effect of Decalepis hamiltonii roots against ethanol-induced oxidative stress. Food Chemistry, 119 (2). pp. 626-629.

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Abstract

The neuroprotective potential of the aqueous extract of the roots of Decalepis hamiltonii (D. hamiltonii root aqueous extract-DHRAE) was studied against ethanol-induced oxidative stress in the rat brain. Ethanol, single dose (5 g/kg body weight), induced oxidative stress in the rat brain which was evident from the increased lipid peroxidation and protein carbonylation, reduced glutathione, and suppressed activities of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione-S-transferase. Pretreatment of rats with multiple doses of DHRAE, 50 and 100 mg/kg b.w., for 7 consecutive days significantly prevented the ethanol-induced oxidative stress. DHRAE, as such, boosted the antioxidant status of the rat brain. The neuroprotective potential of DHRAE can be attributed to the known antioxidant constituents or its interaction with antioxidant response elements (AREs) which needs to be ascertained

Item Type: Article
Uncontrolled Keywords: Decalepis hamiltonii; Antioxidant enzymes; Lipid peroxidation; Glutathione; Protein carbonyl; Ethanol
Subjects: 500 Natural Sciences and Mathematics > 10 Plants
600 Technology > 08 Food technology > 32 Antioxidants
Divisions: Food Protectants and Infestation Control
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 26 Sep 2010 10:02
Last Modified: 28 Dec 2011 10:18
URI: http://ir.cftri.com/id/eprint/9706

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