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Interaction of Garcinol with Human Serum Albumin

Alvin, Thomas (2010) Interaction of Garcinol with Human Serum Albumin. [Student Project Report]

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Abstract

This Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page.

Item Type: Student Project Report
Additional Information: The present study reports the interaction of garcinol, the bioactive compound isolated from Garcinia indica, with Human Serum Albumin. Studies such as absorbance, fluorescence and circular dichroism exhibited enough evidence of binding of garcinol (100% purified crystals) to HSA. The phenomenon of fluorescence quenching was observed with increased garcinol concentration accompanied with an increase in absorption spectral bands. The binding constant was calculated from a linearized Stern-Volmer plot (A plot of quantum yield as a function of ligand concentration and was found to be equal to 5.445 x 106 M-1. The type of binding was one is to one which indicates strong binding. The CD spectra indicated a gross change in α- helical content (10%), upon binding of garcinol to HSA.
Uncontrolled Keywords: Garcinol; Garcinia indica; Human Serum Albumin; organic compound
Subjects: 600 Technology > 01 Medical sciences > 18 Tropical medicine
500 Natural Sciences and Mathematics > 10 Plants
Divisions: Human Resource Development
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 12 Jul 2010 06:39
Last Modified: 28 Dec 2011 10:15
URI: http://ir.cftri.com/id/eprint/9513

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