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Quercetin as a Modulant Of Oxidative Stress Associated with Diabetic Neuropathy in Streptozotocin Rat Model

Chaitra, S. and Shilpa, K. S. (2010) Quercetin as a Modulant Of Oxidative Stress Associated with Diabetic Neuropathy in Streptozotocin Rat Model. [Student Project Report]

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Abstract

This Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page.

Item Type: Student Project Report
Additional Information: Diabetic neuropathy is one of most common complications of diabetes mellitus. It affects nearly 60% of all diabetics and is prevalent among people with a history of fifteen or more years of diabetes. Researchers from throughout the world have been looking in to the underlying mechanisms for this complication. Various findings converge upon the hypothesis that the oxidative stress building up due to hyperglycaemia is the root cause for cell dysfunction and degeneration, hence affecting the nervous system as a whole. Both peripheral and autonomic functions are affected. Keeping this view in mind, biochemists and cell biologists, are trying to channel the antioxidant properties of various flavonoids to rescue the cells and / or prevent further damage by hyperglycaemia induced oxidative stress. Quercetin is one such flavonoid that is ubiquitously present in fruits, vegetables and various spices. It has been well documented that it inhibits lipid peroxidation, chelate iron and directly scavenge hydroxyl, peroxy and superoxide radicals. Hence, the present study examined the potential of quercetin to protect against diabetic neuropathy associated oxidative stress employing Streptozotocin (STZ) rat model.
Uncontrolled Keywords: quercetin; diabetic neuropathy; oxidative stress; flavonoid
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 18 Flavonoid Chemistry
600 Technology > 01 Medical sciences > 04 Diabetes Mellitus
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 28 Jun 2010 04:46
Last Modified: 28 Dec 2011 10:14
URI: http://ir.cftri.com/id/eprint/9435

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