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Bioavailability and metabolism of fucoxanthin in rats: structural characterization of metabolites by LC-MS (APCI)

Ravi Kumar, Sangeetha and Narayan, Bhaskar and Soundar, Divakar and Vallikannan, Baskaran (2010) Bioavailability and metabolism of fucoxanthin in rats: structural characterization of metabolites by LC-MS (APCI). Molecular and Cellular Biochemistry, 333. pp. 299-310.

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Abstract

This study reports bioavailability and metabolism of fucoxanthin (FUCO) from brown algae Padina tetrastromatica in rats. Rats were divided into two groups (n = 25/group). Group one was fed basal diet (control) while the group two received retinol deficient diet (RD group) for 8 weeks. After confirmed RD in blood (0.53 lmol/l), rats were further sub-grouped (n = 5/sub group), intubated a dose of FUCO (0.83 lmol) and killed after 0, 2, 4, 6 and 8 h. The plasma levels (area under curve/8 h) of FUCO (fucoxanthinol (FUOH) ? amarouciaxanthin (AAx)) was 2.93 (RD group) and 2.74 pmol/dl (control), respectively. No newly formed retinol was detected in RD rats intubated with FUCO. Besides FUOH (m/z 617 (M?H)?) and AAx (m/z 617 (M?H-)?), other deacetylated, hydrolyzed and demethylated metabolites of bearing molecular mass at m/z 600.6 (FUOH–H2O), m/z 597 (AAx–H2O), m/z 579 (AAx–2H2O?1), m/z 551 (AAx– 2H2O–2CH3?2) and m/z 523 (AAx–2H2O–4CH3?4) were also detected in plasma and liver by LC-MS (APCI). Although biological functions of FUCO metabolites need thorough investigation, this is the first detailed report on FUCO metabolites in rats.

Item Type: Article
Uncontrolled Keywords: Amarouciaxanthin Fucoxanthin Fucoxanthinol LC-MS Retinol
Subjects: 500 Natural Sciences and Mathematics > 07 Life Sciences > 04 Microbiology > 01 Algae
600 Technology > 08 Food technology > 16 Nutritive value > 04 Vitamins
Divisions: Dept. of Biochemistry
Meat Fish and Poultry Technology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 26 Feb 2010 11:46
Last Modified: 22 Oct 2018 06:22
URI: http://ir.cftri.com/id/eprint/9371

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