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Comparative effects of b-carotene and fucoxanthin on retinol deficiency induced oxidative stress in rats

Sangeetha, R. K. and Bhaskar, N. and Baskaran, V. (2009) Comparative effects of b-carotene and fucoxanthin on retinol deficiency induced oxidative stress in rats. Molecular and Cellular Biochemistry, 331. pp. 59-67.

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Abstract

This study aimed at comparing antioxidant potential of fucoxanthin (FUCO) with b-carotene in relieving lipid peroxidation (Lpx) caused by retinol deficiency (RD) in rats. RD rats (n = 45) were fed a dose of either b-carotene (0.81 lmol) or FUCO (0.83 lmol). Plasma and liver lipid peroxide levels and activity of antioxidant enzymes catalase (CAT) and glutathione transferase (GST) were measured for 8 h. Results revealed that RD increased (P\0.05) Lpx in plasma and liver by 34.3% and 19.4%, while the CAT activity in plasma (89%) and liver microsomes (91%) and GST in liver homogenate (31%) and liver microsomes (30%) were decreased (P\0.05) compared to control (rats fed basal diet). FUCO suppressed (P\0.05) the Lpx level by 7–85% (plasma) and 24–72% (liver) as compared to b-carotene (51–76%, 33–65%) over a period of 8 h. The activity of CAT in plasma and liver microsomes was higher (P\0.05) in FUCO (90–95%, 85–93%) and b-carotene (87–96%, 79– 91%) groups as compared to RD group. Similarly, the activity of GST in liver and its microsomes was also elevated (P\0.05) in FUCO (44–51%, 22–51%) and b-carotene (19–54%, 30–43%) groups as compared to RD group. Results demonstrate that FUCO has greater potential than b-carotene in modulating Lpx, CAT, GST in plasma and liver of RD rats.

Item Type: Article
Uncontrolled Keywords: b-Carotene Fucoxanthin Lipid peroxidation Retinol deficiency
Subjects: 600 Technology > 08 Food technology > 16 Nutritive value > 04 Vitamins
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 26 Feb 2010 11:43
Last Modified: 28 Dec 2011 10:13
URI: http://ir.cftri.com/id/eprint/9370

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