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Ulcer preventive and antioxidative properties of astaxanthin from Haematococcus pluvialis

Sandesh Kamath, B. and Srikanta, B. M. and Shylaja, M. Dharmesh and Sarada, R. and Ravishankar, G. A. (2009) Ulcer preventive and antioxidative properties of astaxanthin from Haematococcus pluvialis. European Journal of Pharmacology, 590. pp. 387-395.

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Abstract

The anti-ulcer properties of astaxanthin fractions such as total carotenoid and astaxanthin esters from Haematococcus pluvialis were evaluated in ethanol-induced gastric ulcers in rats. Since oxygen radical release is a pathogenic factor of ethanol-induced gastric damage, astaxanthin — a free radical scavenger, was investigated as a potential ulcer preventive agent. Astaxanthin fractions — total carotenoid and astaxanthin esters were orally administered to experimental rats at 100, 250 and 500 μg/kg b.w. prior to ulcer induction. Alcian blue binding assay indicates that, total carotenoid and astaxanthin esters at 500 μg/kg b.w could protect gastric mucin ~40% and 67% respectively. Pre-treatment with astaxanthin esters, also resulted in significant increase in antioxidant enzyme levels — catalase, superoxide dismutase, and glutathione peroxidase in stomach homogenate. Histopathological examination substantiated the protective effect of astaxanthin in pre-treated rats. The increased antioxidant potencies such as free radical scavenging activity with an IC50 of ~8 μg/ml and reducing power abilities (59×103 U/g) in vitro, reveal that H. pluvialis astaxanthin may protect gastric mucosal injury by antioxidative mechanism. In addition, ~23 fold increased lipoxygenase-inhibitory property, in comparison with standard astaxanthin and significant H+, K+-ATPaseinhibitory activity of astaxanthin esters, in comparison with known proton pump blocking anti-ulcer drug — omeprazole, may envisage the potential gastroprotective effect by regulating the gastric mucosal injury and gastric acid secretion by the gastric cell during ulcer disease.

Item Type: Article
Uncontrolled Keywords: Astaxanthin Haematococcus Antioxidant Gastroprotective
Subjects: 500 Natural Sciences and Mathematics > 07 Life Sciences > 04 Microbiology > 01 Algae
600 Technology > 08 Food technology > 32 Antioxidants
Divisions: Dept. of Biochemistry
Plant Cell Biotechnology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 15 Jun 2009 06:35
Last Modified: 01 Jul 2015 12:10
URI: http://ir.cftri.com/id/eprint/9090

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