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Reno-protective effects of fenugreek (Trigonella foenum greacum) during experimental diabetes

Shetty, Ajaya K. and Salimath, P. V. (2009) Reno-protective effects of fenugreek (Trigonella foenum greacum) during experimental diabetes. European Journal of Clinical Nutrition and Metabolism, 4 (3). e137-e142. ISSN 1751-4991

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SummaryBackground & aims Diabetes induced structural/functional alterations of glycosaminoglycan heparan sulfate (HS) and type-IV collagen in glomerular basement membrane are linked to renal failure. The objective of this study was to investigate the reno-protective effect of fenugreek in the streptozotocin induced diabetic rats with an emphasis on HS and type-IV collagen.Method Diabetes was induced in rats by streptozotocin and the experimental groups were fed either with or without fenugreek powder at 5% level in the diet.Results Fenugreek in the diet showed a marked decrease in diabetes induced polydypsia, polyuria, urine sugar, hyperglycaemia, renal hypertrophy and glomerular filtration rate. Increased activities of renal enzymes involved in the synthesis/degradation of glycosaminoglycans (l-glutamine fructose-6-phosphate aminotransferase, N-acetyl glucosaminidase and [beta]-glucuronidase) were significantly lowered by fenugreek supplementation during diabetes. Sulfated glycosaminoglycans and their components (amino sugar, uronic acid and sulfate) revealed decreasing trends during diabetes and fenugreek effectively countered this decrease. Diabetic kidneys showed 36% decrease in HS content in comparison to normal kidneys, and this decrease was significantly reduced to 20% by incorporating fenugreek in the diet. Increase in the total collagen content, deposition of type-IV collagen and periodic acid-Schiff-positive material in the glomerulus during diabetes were effectively countered by a fenugreek-incorporated diet.Conclusions Taken together, our results show the beneficial effects of fenugreek in reducing kidney damage during diabetes.

Item Type: Article
Uncontrolled Keywords: Diabetes Glycosaminoglycans Heparan sulfate Type-IV collagen Fenugreek
Subjects: 600 Technology > 01 Medical sciences > 04 Diabetes Mellitus
600 Technology > 08 Food technology > 30 Spices/Condiments > 08 Fenugreek
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 23 Feb 2018 08:26
Last Modified: 23 Feb 2018 08:26
URI: http://ir.cftri.com/id/eprint/9070

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