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Safety evaluation of arachidonic acid rich Mortierella alpina biomass in albino rats--A subchronic study

Nisha, A. and Muthukumar, S. P. and Venkateswaran, G. (2009) Safety evaluation of arachidonic acid rich Mortierella alpina biomass in albino rats--A subchronic study. Regulatory Toxicology and Pharmacology, 53 (3). pp. 186-194. ISSN 0273-2300

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Abstract

Safety evaluation of arachidonic acid rich Mortierella alpina biomass was carried out in Wistar rats by acute and subchronic oral toxicity studies. A preliminary acute toxicity study revealed that the biomass was safe at acute doses and that the LD50 exceeded 5000mg/kg BW, the highest dose used in the study. In subchronic study, rats were fed diet containing 0, 2500, 5000, 10,000, 20,000 and 30,000mg/kg, M. alpina biomass for a period of 13 weeks. Results indicated that biomass fortification had a positive influence on growth with no overt toxic effects on the survival, food consumption and body weight gain throughout the treatment interlude. The statistically significant changes in relative organ weights, serum biochemical and hematological indices in M. alpina fed groups' viz., higher relative weights of spleen, liver, brain and ovary in females, reduced hemoglobin concentration in males, elevated WBC counts at highest dose, reduction in serum triglycerides and increased alkaline phosphatase activity were not concomitant with pertinent histopathological changes and hence toxicologically inconsequential. No microscopic or macroscopic lesions attributable to the treatment were manifested in the experimental groups. The results of the present study strongly advocate the safety of M. alpina biomass in rats at levels used in the study.

Item Type: Article
Uncontrolled Keywords: Mortierella alpina Arachidonic acid Infant formula Histopathology Safety studies
Subjects: 500 Natural Sciences and Mathematics > 07 Life Sciences > 04 Microbiology > 01 Algae
600 Technology > 08 Food technology > 13 Quality control > 02 Safety
Divisions: Food Microbiology
Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 18 Jun 2009 04:25
Last Modified: 28 Dec 2011 10:09
URI: http://ir.cftri.com/id/eprint/9057

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