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Studies on effect of dietary ethionine on tissue acid mucopolysaccharides.

Srinivas, H. and Srinivas, L. and Rao, P. B. R. (1972) Studies on effect of dietary ethionine on tissue acid mucopolysaccharides. Nutrition Reports International, 6 (3). pp. 145-156.

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Abstract

The effect of a supplement of DL-ethionine on tissue acid mucopolysaccharides (MPS) of rats maintained on a low-protein diet (9% casein) was studied. The incorporation of 35S (Na35SO4) into lipids and MPS was also studied. MPS were isolated from tissues after proteolytic digestion by pepsin and trypsin. Liver intestine and kidney MPS showed increased amounts, in g of tissue, of uronic acid and hexosamine in the ethionine-fed group. Increases in associated protein and neutral sugar content were observed in intestinal and liver MPS. Fractionation of liver and intestinal MPS showed increases in the "chondroitin sulphates" in the ethionine-fed group. Intestinal MPS isolated after digestion of tissue by pronase showed decreased MPS content (uronic acid) and rduced incorporation of 35S in the ethionine-fed group. This decrease was prevented by methionine supplementation. The studies showed that ethionine administration results primarily in an accumulation of neutral glycoproteins and alters the proportion of sulphated and non-sulphated tissue MPS.

Item Type: Article
Uncontrolled Keywords: mucopolysaccharides-; tissues-; ethionine-
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 28 Polysaccharide Chemistry
600 Technology > 08 Food technology > 18 Processed foods > 01 Dietary Fiber
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 20 Dec 2016 06:16
Last Modified: 20 Dec 2016 06:16
URI: http://ir.cftri.com/id/eprint/8606

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