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Effect of dietary fiber on the activity of intestinal and fecal beta-glucuronidase activity during 1,2-dimethylhydrazine induced colon carcinogenesis.

Manoj, G. and Thampi, B. S. H. and Leelamma, S. and Menon, P. V. G. (2001) Effect of dietary fiber on the activity of intestinal and fecal beta-glucuronidase activity during 1,2-dimethylhydrazine induced colon carcinogenesis. Plant Foods for Human Nutrition, 56 (1). 13-21, 22 ref..

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Abstract

Effects of fibre isolated from black gram (Phaseolus mungo) and coconut (Cocos nucifera) kernel on activity of intestinal and faecal beta-glucuronidase during 1,2-dimethylhydrazine (DMH) induced colon carcinogenesis were studied using an animal model. beta-Glucuronidase has been shown to be a key enzyme in metabolism of DMH in the colon, to produce carcinogens. Sprague-Dawley male albino rats were given 1 of 3 diets, a fibre-free diet (control), a 30% black gram fibre containing diet or a 30% coconut fibre containing diet. Each group was treated weekly with DMH injections (20 mg/kg body wt.) for 15 wk. Intestinal and faecal beta-glucuronidase activities were determined weekly. Results indicated that inclusion of fibre from either source generally supported lower specific activities and less faecal output of beta-glucuronidase than did the fibre-free diet. It is suggested that the fibres isolated from coconut or black gram may potentially play a role in preventing formation of colonic tumours induced by the carcinogen DMH by reducing activity of intestinal and faecal beta-glucuronidase.

Item Type: Article
Uncontrolled Keywords: FIBRE-; GLYCOSIDASES-; HEALTH-; beta-GLUCURONIDASES; ANIMAL-MODELS; ANTICARCINOGENICITY-; DIETARY-FIBRE
Subjects: 600 Technology > 08 Food technology > 18 Processed foods > 01 Dietary Fiber
600 Technology > 08 Food technology > 22 Legumes-Pulses
Divisions: Plant Cell Biotechnology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 19 Jul 2011 04:13
Last Modified: 28 Dec 2011 10:00
URI: http://ir.cftri.com/id/eprint/7662

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