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Modulation of cholesterol induced hypercholesterolemia through dietary factors in Indian desert gerbils (Meriones hurrianae).

Ramachandran, H. D. and Narasimhamurthy, K. and Raina, P. L. (2003) Modulation of cholesterol induced hypercholesterolemia through dietary factors in Indian desert gerbils (Meriones hurrianae). Nutrition Research, 23 (2). pp. 245-256.

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Abstract

Modulation of cholesterol metabolism in cholesterol-fed male Indian desert gerbils (Meriones hurrianae) was examined, using a diet formulated to contain various n-6/n-3 fatty acid profiles. 6-wk old gerbils of approx. 120 g were used in groups of 6, fed either coconut oil (CNO), crude palm oil (CPO) or soybean oil (SBO) at 10% in a basal ration containing 68.2-69.5% ragi flour and 15% bengal gram flour, as well as 0 or 1% cholesterol. Diets and water were provided ad lib. for 12 wk. Blood and tissue samples were collected for biochemical analyses. The 3 diets had PUFA:saturated fatty acid ratios of 0.01 (CNO), 0.28 (CPO) and 3.01 (SBO). Total serum cholesterol averaged 44.92, 47.45 and 50.48 mg/dl in SBO, CPO and CNO rations without added cholesterol, vs. 46.1, 48.72 and 52.71 mg/dl in corresponding rations with added cholesterol. HDL-cholesterol levels were, correspondingly, 33.44, 31.87 and 30.97% of total cholesterol (no added cholesterol) and 36.6, 31.86 and 28.2% (added cholesterol); LDL-cholesterol + VLDL-cholesterol percentages were, correspondingly, 14.87, 16.43 and 18.98, vs. 17.36, 19.28 and 19.35%. Serum triglyceride levels in SBO, CPO and CNO fed gerbils were, respectively, 3.07, 3.54 and 3.76 mg/dl (no added cholesterol), vs. 2.99, 3.8 and 3.91 mg/dl (added cholesterol); phospholipid levels averaged, correspondingly, 16.29, 17.22 and 15.45 mg/dl, vs. 15.28, 17.1 and 14.59 mg/dl. Liver, heart and biliary lipid profiles of gerbils were also examined. Overall, SBO-containing rations reduced tissue and serum cholesterol levels, followed by CPO-containing rations.

Item Type: Article
Uncontrolled Keywords: CHOLESTEROL-; DIET-; OILS-VEGETABLE; PALM-OILS; PHOSPHOLIPIDS-; SOYBEAN-OILS; TRIGLYCERIDES-; ANIMAL-MODELS; COCONUT-OILS
Subjects: 600 Technology > 08 Food technology > 11 Food Biochemistry
Divisions: Dept. of Biochemistry
Depositing User: Users 197 not found.
Date Deposited: 22 Jun 2011 10:56
Last Modified: 28 Dec 2011 09:59
URI: http://ir.cftri.com/id/eprint/7592

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