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Interaction of piperine with rat liver microsomes.

Ganesh Bhat, B. and Chandrasekhara, N. (1987) Interaction of piperine with rat liver microsomes. Toxicology, 44 (1). 91-98, 23 ref..

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Abstract

Pretreatment of adult male albino rats with piperine [the major pungent factor of black pepper] did not induce cytochrome P-450 whereas safrole did cause such induction. Piperine and safrole interacted with different forms of cytochrome P-450 as indicated by their in vivo effect on drug metabolising enzymes and mixed function oxidases and electrophoretic patterns. Incubation of piperine or safrole with dithionite- or NADPH-reduced microsomes from untreated rats resulted in a modified type II difference spectrum with an absorption max. at 427 nm and a trough at 408 nm.

Item Type: Article
Uncontrolled Keywords: SPICES-; piperine, hepatotoxicity of; pepper, physiological effects of black; ALKALOIDS-; TOXICITY-
Subjects: 600 Technology > 08 Food technology > 30 Spices/Condiments
600 Technology > 01 Medical sciences > 12 Metabolism
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 17 Jun 2011 09:48
Last Modified: 28 Dec 2011 09:52
URI: http://ir.cftri.com/id/eprint/6308

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