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Testicular atrophy in Gallus domesticus fed acute doses of copper fungicides.

Shivanandappa, T. and Krishnakumari, M. K. and Majumder, S. K. (1983) Testicular atrophy in Gallus domesticus fed acute doses of copper fungicides. Poultry Science, 62. pp. 405-408.

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Acute oral toxicity of tbe copper fungicidcs, copper sulphate and copper oxychloride, were studied in male Gallus domesticus. The median lethal dose for copper sulphate and coppler oxychloride determined Were 693 and 1263 mg/kg body weight, respectively. Severe diarrhea and delayed mortality (3 to 6 days) was characteristic of copper oxychloride. Liver weights were nearly doubled in birds fed copper oxychloride and marked dose-dependent testicular atrophy was noticed in both copper sulphate and copper oxychloride fed birds. Mild to severe spermatogenetic arrest concomitam with testicular atrophy WaS observed. Histochemically, the interstitial (Leydig) cells and seminiferous tubules showed intense accumulation of cholesterol· positive lipids. The degree of lipophilia appeared to be directly proportiooal to the extent of spermatogenetic arrest. and these results are suggestive of steroidogenic inhibition in the Leydig cells of the atrophied restis.

Item Type: Article
Uncontrolled Keywords: toxicity, testicular atrophy, lipids, spermatogenesis
Subjects: 600 Technology > 01 Medical sciences > 17 Toxicology
Divisions: Food Protectants and Infestation Control
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 23 Jun 2016 07:51
Last Modified: 23 Jun 2016 07:51
URI: http://ir.cftri.com/id/eprint/5932

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