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Studies on dietary choline defficiency in the rats fed on isolated groundnut protein.

Anantharaman, K. and Paul Jayaraj, A. and Subramanian, N. (1964) Studies on dietary choline defficiency in the rats fed on isolated groundnut protein. Bulletin of National Institute of Science India, 25. pp. 90-100.

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At 20% isolated groundnut protein and 0.01 % choline in the diet, the fatty infiltration in the livers during the earlier weeks of growth was 26-30% on fresh weight as compared to 11 % in the livers of rats maintained on 10% of the same protein and 0.01 % choline. Xanthine and succinic oxidase activities were significantly increased and comparable to the group provided with an optional supplement of choline (0.1 %) at the end of 16 weeks. Significant increase in the non-protein nitrogenous fraction was observed in the choline deficient group in the early stages. The major increase in liver lipids (stainable fat) was concurrent with a significant decrease of liver phospholipids in the choline deficient group. Histological studies provided further evidence that fatty metamorphosis of the liver by itself did not lead to hepatic necrosis or cirrhosis and that even at this stage of abnormal centrolobular fatty infiltration, parenchymal damage had not taken place. The functional portal tract remained unaffected even in the initial stages of very severe centrolobular fatty infiltration of the livers of the choline deficient rats. At the end of 16 weeks, the liver sections of rats in this group showed normal histological picture excepting for a few fatty vacuoles. The results are discussed in the light of the importance of choline in both experimental and clinical nutrition.

Item Type: Article
Uncontrolled Keywords: groundnut protein, metabolism, choline deficiency
Subjects: 600 Technology > 01 Medical sciences > 11 Malnutrition
600 Technology > 08 Food technology > 22 Legumes-Pulses > 03 Peanut
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 02 Aug 2013 09:14
Last Modified: 02 Aug 2013 09:14
URI: http://ir.cftri.com/id/eprint/5598

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