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Liver and erythrocyte L-aspartate: and L-alanine: 2-oxoglutarate aminotransferases of the pyridoxine deficient rat.

Radhakrishnamurthy, R. and Sabry, Z. I. (1968) Liver and erythrocyte L-aspartate: and L-alanine: 2-oxoglutarate aminotransferases of the pyridoxine deficient rat. Canadian Journal of Biochemistry, 46. pp. 1081-1088.

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Abstract

The withdrawal of pyridoxine from the diet of male weading rats did not appear to affect the liver mitochondrial L-aspartate : 2-oxoglutarate amhotransferase, but the ismnzymes in the liver supematant and in the erythrocyte showed gradual lowering of activity. The liver kalanine : Zoxoglutarate aminatransferase activity (mostly residing in the supernatant) showed a sharp and immediate decline, and that of the erythrocyte exhibited a more gradual decline with the progress of deficiency. The liver supernatant and erythrocyte aspartate aminotransferases of the deficient animals showed a marked recowry with subcutaneous injection of pyridoxine and in vitro addition of pyridoxal-5-phosphate to the enzyme system. The data emphasize the sensitivity of the supernatant and erythrocyte aspartate aminotransfemses in reflecting the pyridoxine nutritional state of the rat.

Item Type: Article
Uncontrolled Keywords: L-aspartate, 2-oxoglutarate aminotransferase, isoenzymes
Subjects: 500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 07 Enzyme Biochemistry
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 07 Mar 2018 06:14
Last Modified: 07 Mar 2018 06:14
URI: http://ir.cftri.com/id/eprint/4570

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