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Interrelationships between vitamin B12 and patothenic acid in the rat in experimental thyrotoxicosis.

Aiyar, A. S. and Sreenivasan, A. (1962) Interrelationships between vitamin B12 and patothenic acid in the rat in experimental thyrotoxicosis. Indian Journal of Medical Research, 50. pp. 262-266.

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A general increase in metabolic rate in the hyperthyroid animal, leading to an enhanced requirement of several growth essentials, including vitamin B12, has been reported in literature (Emerson, 1949 ; Betheil and Lardy, 1949 ; Sure and Easterling, 1950 ; Kasbekar et ah, 1959). The retardation of growth in animals and derangements in various phases of metabolism followed subsequently by a high mortality rate are partially counteracted by supplementation with vitamin B12 (Kasbekar et al., loc. cit.). On the basis of their observations on their reversal, by vitamin B12, of many of the changes resulting from hyperthyroidism, Fatterpaker et al. (1955) indicate that the primary manifestation of thyrotoxicosis is a deficiency of vitamin B12 and that vitamin B12 probably acts by restoration, in part at least, of oxidative phosphorylation. Kasbekar et al. (loc. cit.) in a detailed study of the effect of thyrotoxicosis on mitochondrial morphology, composition and function, observe that the depletion of liver stores of vitamin B12 is followed by a major derangement in the metabolism of soluble sulfhydryl compounds and that these are corrected by vitamin B12. Protective effects of dietary magnesium (Baltcheffsky, 1956 ; Vitale et al, 1957; Gershoff et al., 1958) and of methionine (Boldt et al, 1958) against several metabolic disturbances occurring in thyrotoxicosis are also known. In view of the metabolic relationship between vitamin B12 and pantothenic acid (Aiyar and Sreenivasan, 1961), it was thought of interest to study the changes in the metabolism of coenzyme A and related sulfhydryl compounds in hyperthyroidism, as also the protection afforded by vitamin B12, magnesium and l-methίonine against these changes.

Item Type: Article
Uncontrolled Keywords: thyrotoxicosis, vitamin B12, pantothenic acid, metabolic relationship
Subjects: 600 Technology > 01 Medical sciences > 17 Toxicology
600 Technology > 08 Food technology > 16 Nutritive value > 04 Vitamins
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 18 Jul 2012 09:32
Last Modified: 18 Jul 2012 09:32
URI: http://ir.cftri.com/id/eprint/4496

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