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14-Aminotetradecanoic acid exhibits antioxidant activity and ameliorates xenobiotics-induced cytotoxicity

Anup, Srivastava and Jagan Mohan Rao, L. and Shivanandappa, T. (2012) 14-Aminotetradecanoic acid exhibits antioxidant activity and ameliorates xenobiotics-induced cytotoxicity. Molecular and Cellular Biochemistry, 364 (1-2). pp. 1-9. ISSN 0300-8177

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Abstract

Natural compounds with free-radical scavenging activity have potential role in maintaining human health and preventing diseases. In this study, we report the antioxidant and cytoprotective properties of 14-aminotetradecanoic acid (ATDA) isolated from the Decalepis hamiltonii roots. ATDA is a potent scavenger of superoxide (O2 •-), hydroxyl (•OH), nitric oxide (•NO), and lipid peroxide (LOO•) physiologically relevant free radicals with IC50 values in nM (36–323) range. ATDA also exhibits concentration-dependent secondary antioxidant activities like reducing power, metal-chelating activity, and inhibition of protein carbonylation. Further, ATDA at nM concentration prevented CuSO4-induced human LDL oxidation. ATDA demonstrated cytoprotective activity in primary hepatocytes and Ehrlich ascites tumor cells against oxidative stress inducing xenobiotics apart from the in vitro free-radical scavenging activity. The mechanism of cytoprotective action involved maintaining the intracellular glutathione, scavenging of reactive oxygen species, and inhibition of lipid peroxidation. It is suggested that ATDA is a novel bioactive molecule with potential health implications.

Item Type: Article
Uncontrolled Keywords: 14-Aminotetradecanoic acid � Decalepis hamiltonii Antioxidant ROS Lipid peroxidation Glutathione
Subjects: 500 Natural Sciences and Mathematics > 10 Plants
600 Technology > 08 Food technology > 32 Antioxidants
Divisions: Food Protectants and Infestation Control
Plantation Products Spices and Flavour Technology
Depositing User: Users 197 not found.
Date Deposited: 16 Aug 2011 09:11
Last Modified: 06 Mar 2013 08:55
URI: http://ir.cftri.com/id/eprint/4436

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