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Induction of liver mixed function oxygenase system by beta- and gamma-hexachlorocyclohexane.

Srinivasan, K. and Radhakrishnamurthy, R. (1983) Induction of liver mixed function oxygenase system by beta- and gamma-hexachlorocyclohexane. Indian Journal of Biochemistry and Biophysics, 20. pp. 84-91.

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Abstract

The y- isomer of hexachlorocydohexane(HCH) was a more powerful inducer ofmilted function oxygenase system (M FOS) than the beta- isomer, although the increases in liver weights were more in beta-HCH-treated rats. Induction of MFOS by these HCH isomers was dose-dependent even 50 ppm dietary level (or 2 weeks was effective. MFOS induction was nearly maximum at the end of 4 days treatment. Increases in cytochromes P450 and bs, produced by these compounds were not associated with stimulation of heme synthesis. Stimulation of cytochromes, O-hydroxylase, and N-demethylase by HCH isomers and phenobarbital was not additive when administered togetber. /1- or)'- HCH and phenobarbital produced an additive effect on the induction ofNADPH-eytochrome reductase. Exogenous administration of hematin counteracted the induction ofMFOS by HeH isomers, as in the case of phenobarbital.

Item Type: Article
Uncontrolled Keywords: mixed function oxygenase system, enzymes, hexachlorocyclohexane,
Subjects: 500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 07 Enzyme Biochemistry
600 Technology > 01 Medical sciences > 12 Metabolism
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 24 Jun 2016 06:11
Last Modified: 24 Jun 2016 06:11
URI: http://ir.cftri.com/id/eprint/4388

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