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Hydrolysis of D,L-tryptophan isopropyl este catalysed by Beta-cyclodextrin.

Ravichandran, R. and Divakar, S. (1996) Hydrolysis of D,L-tryptophan isopropyl este catalysed by Beta-cyclodextrin. Indian Journal of Chemistry, 35A (6). pp. 504-507.

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Abstract

ß-Cyclodextrin (BCD) catalysed hydrolysis of D,Ltryptophan isopropyl ester is found to be pH dependent. The pH rate constant profiles show that the kobs values for the BCD catalysed reactions are higher than those of the control in the pH range 9.8 to 12.9. The reaction follows Michaelis-Menten type kinetics exhibiting substrate saturation. Michaelis-Menten treatment results in determination of KD (0.067 M) and kcat (0.015 M-1 min-1). A kcat/kun values of 0.94 has been determined. Tryptophan, the hydrolysis product formed exhibited enantiometric excess of 7.9 to 18.4% of the ( -) antipode in reactions catalysed by BCD, heptakis-2,6- di-O-methyl-ß-cyclodextrin (DM-BCD), BCD-epichlorohydrin polymer (BCD-polymer) and a 1:1 complex of Cu(II)-ß-cyclodextrin(Cu(II)-BCD).

Item Type: Article
Uncontrolled Keywords: ß-Cyclodextrin
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 24 Organic Chemistry
Divisions: Food Microbiology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 19 Apr 2012 04:03
Last Modified: 19 Apr 2012 04:03
URI: http://ir.cftri.com/id/eprint/4329

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