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Hexachlorocyclohexane-induced testicular dysfunction in rats.

Shivanandappa, T. and Krishnakumari, M. K. (1983) Hexachlorocyclohexane-induced testicular dysfunction in rats. Acta Pharmacologia and Toxicologie, 52. pp. 12-17.

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Weanling male albino rats were fed 100, 750 and 1500 p.p.m. oftechnical HCH for90days. There was marked testicular atrophy with reduced tubule size and spermatogenetic arrest at 1500 p.p.m. Histochemically, there was accumulation of cholesterol-positive lipids in the Sertoli cells and the Leydig cells of the atrophied testis and biochemical estimation revealed significant increase of total lipid and cholesterol contents. Activities of As 3 0 hydroxysteroid dehydrogenase (A5 3 0 HSDH), 17 p hydroxysteroid dehydrogenase( I7 HSDH)and glucose-6-phosphate dehydrogenase (G-6-PDH) in the interstitial cells were markedly decreased suggesting steroidogenic inhibition in the Leydig cells of the atrophied testis due to HCH feeding.

Item Type: Article
Uncontrolled Keywords: Hexachlorocyclohexane - spermatogenesis - steroidogenesis - lipid - cholesterol - hydroxysteroid - de h ydrogenases
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 26 Pesticide Chemistry
600 Technology > 01 Medical sciences > 17 Toxicology
Divisions: Food Protectants and Infestation Control
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 12 Mar 2018 09:40
Last Modified: 12 Mar 2018 09:40
URI: http://ir.cftri.com/id/eprint/4317

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