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Effect of beta- and gamma-isomers of hexachlorocyclohexane on some liver and kidney enzymes in albino rats.

Srinivasan, K. and Radhakrishnamurthy, R. (1977) Effect of beta- and gamma-isomers of hexachlorocyclohexane on some liver and kidney enzymes in albino rats. Current Science, 46. pp. 598-600.

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Abstract

PESTAB. Weanling male rats were maintained for 14-18 days on diets containing no pesticide (controls) or 800 ppm of beta-BHC or gamma-BHC. The animals were observed for 2 weeks and sacrificed during the third week. Protein and the activities of alanine and asparatate 2-oxoglutarate aminotransferase, alkaline and acid phosphatase, glucose-6-phosphatase, and glucose-6-phosphate dehydrogenase in the liver and kidney tissues were determined. During the third week, beta-BHC produced signs of severe toxicity culminating in coma and death; it produced no growth retardation. gamma-BHC produced loss of apetite and growth retardation during the first week only. beta-BHC produced significant increases in hepatic alanine aminotransferase (80%), the renal alkaline and acid phosphatase (125% and 35%, respectively), and hepatic glucose-6-phosphate dehydrogenase (130%), and significant decreases in hepatic aspartate aminotransferase (30%), renal alanine aminotransferase (35%), the hepatic alkaline and acid phosphatases (45% and 40%, respectively), and hepatic glucose-6-phosphatase (30%). gamma-BHC produced significant increase in hepatic alanine aminotransferase (50%), renal acid phosphate dehydrogenase (40%), and significant decreases in hepatic aspartate aminotransferase (30%) and the hepatic alkaline and acid phosphatases (35% each).

Item Type: Article
Uncontrolled Keywords: toxicity, hexachlorocyclohexane, insecticidal action
Subjects: 500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 07 Enzyme Biochemistry
600 Technology > 01 Medical sciences > 17 Toxicology
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 05 Feb 2015 07:14
Last Modified: 05 Feb 2015 07:14
URI: http://ir.cftri.com/id/eprint/3841

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