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Oxidative Stress Mediated Cytotoxicity Of Lindane And It’s Amelioration By Antioxidants

Anju, Abraham (2006) Oxidative Stress Mediated Cytotoxicity Of Lindane And It’s Amelioration By Antioxidants. [Student Project Report]

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Abstract

This Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page.

Item Type: Student Project Report
Additional Information: Induction of cellular injury / cell death by Lindane;role of oxidative stress with specific reference to ROS; and amelioration of cellular oxidative stress by antioxidants was investigated. Mechanism of lindane induced cytotoxicity was studied in EAT cells. Lindane caused dose and time dependent cytotoxic injury to EAT cells as evident from cell viability and LDH leakage. Lindane induced the generation of ROS in a dose-dependent manner and depleted GSH level which led to oxidative stress and ultimately cell death. Induction of DT-diaphorase was a characteristic feature of lindane cytotoxicity to EAT cells. Quercetin, a bioflavonoid ameliorated the cytotoxic effect of lindane by suppressing ROS generation, glutathione depletion and cell death. The novel antioxidant, 4-hydroxyisophthalic acid from D.hamiltonii showed cytoprotective effect against lindane cytotoxicity at a much lower concentration, suggesting its ameliorative potential.
Uncontrolled Keywords: lindane cytotoxicity lindane antioxidants pesticides oxidative stress
Subjects: 600 Technology > 01 Medical sciences > 17 Toxicology
500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 26 Pesticide Chemistry
600 Technology > 08 Food technology > 32 Antioxidants
Divisions: Food Protectants and Infestation Control
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 22 Dec 2006
Last Modified: 28 Dec 2011 09:26
URI: http://ir.cftri.com/id/eprint/371

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