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Effect Of Butyric Acid Supplementation On Serum And Renal Antioxidant Enzyme Activities In Streptozotocin-Induced Diabetic Rats

Puneeth Kumar, A. and Mallikarjun, Chougala and Nandini, C. D. and Salimath, P. V. (2010) Effect Of Butyric Acid Supplementation On Serum And Renal Antioxidant Enzyme Activities In Streptozotocin-Induced Diabetic Rats. Journal of Food Biochemistry, 34. pp. 15-30.

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Abstract

Reactive oxygen metabolites, which are constant products of normal aerobic cell metabolism, play a key role in worsening the pathophysiological complications of diabetes. The present investigation was aimed at understanding the effect of butyric acid supplementation along with wheatbran and guar gum on serum and renal antioxidant enzyme activities and lipid peroxidation in streptozotocin (STZ)-induced diabetic rats. Activities of superoxide dismutase, catalase, glutathione peroxidase were evaluated in serum and kidney of control and experimental rats. Results clearly showed that the altered activity of the enzymes during diabetes was significantly ameliorated by butyric acid (500 mg/kg body weight/day) supplementation compared with other experimental groups. Further, the increased lipid peroxidation in serum and kidney of diabetic rats was also significantly reduced in butyric acid-supplemented diabetic rats. The study led us to conclude that butyric acid exert antioxidant property, thereby minimizing oxidative stress induced diabetes and its related complications.

Item Type: Article
Uncontrolled Keywords: diabetes; butyric acid supplementation; wheatbran; guar gum; dietary fiber fermentation
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 17 Fatty Acid Chemistry
600 Technology > 01 Medical sciences > 04 Diabetes Mellitus
600 Technology > 08 Food technology > 18 Processed foods > 01 Dietary Fiber
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 13 Sep 2010 11:23
Last Modified: 03 Oct 2018 09:13
URI: http://ir.cftri.com/id/eprint/3469

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