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Studies on the beneficial effects of dietary fiber on experimentally induced diabetic rats with particular emphasis on glomerular filtration matrix

Suresh Kumar, G. (2005) Studies on the beneficial effects of dietary fiber on experimentally induced diabetic rats with particular emphasis on glomerular filtration matrix. Doctoral thesis, University of Mysore.


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Diabetes is a disease of great concern to many all over the world and is characterized by its complications such as diabetic neuropathy,retinopathy and nephropathy. Diabetic nephropathy leading to kidney damage is one of the serious concerns and has aroused lot of research interest. During diabetic nephropathy changes in glomerular basement membrane (GBM) are known to take place making the glomeruli thicker. The structure and composition of GBM is of importance for its function as filtration barrier in the glomerulus. The glomerular filtration matrix, which is essential for normal filtration to take place is formed of heparan sulphate, type IV collagen and laminin. During diabetes thickening of GBM is known to take place due to reduction in heparan sulfate and laminin and accumulation of type IV collagen leading to abnormal filtration. Dietary management of diabetes is now well established to be one of the means in the management of diabetes. In this category, dietary fibers and foods rich in dietary fibers are well accepted to have beneficial functions in the management of diabetes. But there are not many scientific investigations on the role of these dietary fibers in minimizing complications of diabetes, such as diabetic nephropathy. In recent years, fermentation of dietary fibers to short chain fatty acids (SCFA), such as acetate, propionate and butyrate is being increasingly recognized to play beneficial functions in normal physiological condition and also in alleviating pathological conditions such as cancer, diabetes, etc. Our laboratory has shown that butyric acid ameliorates diabetic and diabetic nephropathy state. Among the foods that possess beneficial effects on diabetes, dietary fiber rich foods are one of the important classes. Spent turmeric, a byproduct of turmeric industry is one of the rich sources of dietary fibers.Hence, one of the objectives was to study the effects of dietary fiber rich food, spent turmeric, a by-product of curcumin industry, on diabetic and diabetic nephropathy state with particular emphasis on glycoconjugate metabolism in glomerular basement membrane.

Item Type: Thesis (Doctoral)
Uncontrolled Keywords: Diabetes dietary fiber glomerular filtration matrix
Subjects: 600 Technology > 08 Food technology
600 Technology > 01 Medical sciences > 04 Diabetes Mellitus
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 20 Dec 2006
Last Modified: 11 Oct 2018 09:27
URI: http://ir.cftri.com/id/eprint/344

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