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Studies on DNA Topology and DNA-Amyloid Beta (Aβ) peptides interaction in relevance to Alzheimer's Disease

Anitha, S. (2005) Studies on DNA Topology and DNA-Amyloid Beta (Aβ) peptides interaction in relevance to Alzheimer's Disease. PhD thesis, University of Mysore.


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<p align="justify">Alzheimer's disease (AD) is a complex neurodegenerative disorder of multiple etiology. It is a devastating dementia, correlated with a region specific neuronal cell loss. The complex neuropathology includes cortical atrophy,formation of neurofibrillary tangles, deposition of amyloid β peptide (Aβ) in senile plaques, synaptic loss, oxidative stress, metal deposition, and apoptosis and all these coupled events lead to the neuronal loss. Despite progress in uncovering many of the factors that contribute to the etiology of the disease,the cause of the nerve cell death still remains unknown. It is very well accepted that conformational changes in the proteins namely Aβ play an important role in the neurodegeneration of AD, however little is known about the DNA conformational alteration. The changes in the genetic material of AD, so far documented are, i) mutations in genes, amyloid precursor protein (APP),presenilin-1 (PS-1) and presenilin-2 (PS-2), ii) shift in the DNA from a potentially transcribable euchromatic state to a condensed and probably heterochromatic state, iii) oxidative damage as revealed by damaged products namely 8-OH Guanosine and 8-OH Cytosine and iv) genetic imbalance caused by the tetraploidy status of the genome by the way of unusual replication before the cell death . However there is no data on DNA topology in AD brain. Hence the present study aimed to understand studies pertaining to DNA topology and Aβ-DNA interactions in relevance to neurodegeneration in AD brain.</p>

Item Type: Thesis (PhD)
Uncontrolled Keywords: Alzheimer's Disease DNA Topology DNA Amyloid Beta peptides
Subjects: 600 Technology > 01 Medical sciences > 09 Human Physiology
500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 25 Peptide Chemistry
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 22 Feb 2006
Last Modified: 28 Dec 2011 09:26
URI: http://ir.cftri.com/id/eprint/323

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