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Biochemical changes induced by alpha-naphthylthiourea in albino rats.

Patil, T. N. and Radhakrishnamurty, R. (1978) Biochemical changes induced by alpha-naphthylthiourea in albino rats. Pesticide Biochemistry and Physiology, 8. pp. 217-224.

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Abstract

Administration of alpha-naphthylthiourea to albino rats caused excessive urinary excretions of albumin, inorganic phosphorus, and urea in 22 hr. Levels of inorganic phosphorus, glucose, and creatinine were elevated in blood and in the pleural effusion. Urea contents in blood and pleural effusion were progressively increased with concomitant rise in arginase activities. Significant increases were observed in phospholipids, triglycerides, and cholesterol concentrations in blood. No changes were noticed in cholesterol and fat contents of the liver. Kidney sections showed lesions in the glomerular region after 8 hr, and in the later stages, the histopathological evidence was suggestive of acute glomerular nephritis of the lipoidal type.

Item Type: Article
Uncontrolled Keywords: alpha-naphthylthiourea, rodenticide, acute glomerular nephritis
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 26 Pesticide Chemistry
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 09 Mar 2011 09:33
Last Modified: 23 Oct 2018 10:52
URI: http://ir.cftri.com/id/eprint/3167

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