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Metabolism of vitamin B/sub 12/ in the rat in pantothenic acid deficiency.

Aiyar, A. S. and Sreenivasan, A. (1962) Metabolism of vitamin B/sub 12/ in the rat in pantothenic acid deficiency. Indian Journal of Medical Research, 50. pp. 89-94.

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AMONG the various interrelationships between the members of the B group of vitamins, perhaps the most interesting is that between pantothenic acid and vitamin B12. Reports of elevations in hepatic concentration of coenzyme A in vitamin B12 deficient animals (Boxer et al, 1953, 1955 ; Wong and Schweigert, 1956) have been closely followed by observations of increased stores of vitamin B12 in pantothenic acid-deficient rat livers (Radhakrishnamurthy and Sarma, 1957). This reciprocal relationship between the two vitamins has since been confirmed by several others (Moruzzi et al, 1958 ; Aiyar et al., 1959; Aiyar and Sreenivasan, 1961a). While studies in this laboratory have indicated that the elevation in hepatic coenzyme A stores in vitamin B12 deficiency is due to alterations in the sulfhydryl metabolism resulting in an increased channelling of sulfhydryl reserves of the cell into coenzyme A, rather than into glutathione or methionine (Aiyar and Sreenivasan, 1961a) the increase in liver concentration of vitamin B12 in pantothenic- acid deficiency needs further investigation. The present work relates to studies on the metabolism of vitamin B12 in pantothenic acid-deficient rats. Observations on the alterations in liver and serum levels of vitamin B12, as also in its urinary excretion, are presented and discussed.

Item Type: Article
Uncontrolled Keywords: metabolism, vitamin B12, pantothenic acid
Subjects: 600 Technology > 01 Medical sciences > 12 Metabolism
600 Technology > 08 Food technology > 16 Nutritive value > 04 Vitamins
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 12 Jul 2012 05:01
Last Modified: 12 Jul 2012 05:01
URI: http://ir.cftri.res.in/id/eprint/2708

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