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A study of the metabolism of L-L, y-diamino-butyric acid in a Xanthomonas species.

Rajagopal Rao, D. and Vijayakumar, K. R. and Hariharan, K. (1969) A study of the metabolism of L-L, y-diamino-butyric acid in a Xanthomonas species. Biochemical Journal, 114 (1). pp. 107-115.

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1. L.o::y.Diaminobutyric acid is metabolized in Xanl1wmonas sp. to aspartic ,B.semialdehyde, aspartic acid and oxaloacetic acid. 2. Aspartic ,B.semialdehyde is fonned from diaminobutyric acid by a. pyruvate-dependent y-transamination. 3. The transaminase has a pH optimum of 9 and exhibits a high degree of substrate specificity, as analogues of diaminobutyric acid and pyruvate are inert in the system. The transaminase is inhibited bycarbonyl.binding agents such a.<; hydroxylamine. 4. Aspartic acid is fonned from aspaxt,ic ,B.semialdehyde by an NAD+· dependent dehydrogenation. 5. The dehydrogenase has a pH optimum of8·5 and is a thiol enzyme. It is specific for aspartic ,B.semialdehyde but analogues of NAD+ such as 3-acetylpyrid.ine~adeninedinucleotide and deamino-NAD are partly active in the system. 6. The significance of these reactions is discussed in relation to diaminobutyric acid metabolism in plants ami mammalian systems.

Item Type: Article
Uncontrolled Keywords: neurotoxic amino acid, Diaminobutyric acid, metabolism
Subjects: 600 Technology > 01 Medical sciences > 12 Metabolism
600 Technology > 08 Food technology > 16 Nutritive value > 02 Amino acids
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 17 Jun 2014 05:58
Last Modified: 17 Jun 2014 05:58
URI: http://ir.cftri.com/id/eprint/2615

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