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Studies on Antioxidant Activity of Pomegranate (Punica granatum) Peel Extract Using in Vivo Models

Chidambara Murthy, K. N. and Jayaprakasha, G. K. and Ravendra, P. Singh (2002) Studies on Antioxidant Activity of Pomegranate (Punica granatum) Peel Extract Using in Vivo Models. Journal of Agricultural and Food Chemistry, 50 (17). pp. 4791-4795.

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Abstract

<p align="justify">Pomegranate ( Punica granatum) peel extracts have been shown to possess significant antioxidant activity in various in vitro models. Dried pomegranate peels were powdered and extracted with methanol for 4 h. The dried methanolic extract was fed to albino rats of the Wistar strain, followed by carbon tetrachloride (CCl4), and the levels of various enzymes, such as catalase, peroxidase, and superoxide dismutase (SOD), and lipid peroxidation were studied. Treatment of rats with a single dose of CCl4 at 2.0 g/kg of body weight decreases the levels of catalase, SOD, and peroxidase by 81, 49, and 89% respectively, whereas the lipid peroxidation value increased nearly 3-fold. Pretreatment of the rats with a methanolic extract of pomegranate peel at 50 mg/kg (in terms of catechin equivalents) followed by CCl4 treatment causes preservation of catalase, peroxidase, and SOD to values comparable with control values, wheres lipid peroxidation was brought back by 54% as compared to control. Histopathological studies of the liver were also carried out to determine the hepatoprotection effect exhibited by the pomegranate peel extract against the toxic effects of CCl4. Histopathological studies of the liver of different groups also support the protective effects exhibited by the MeOH extract of pomegranate peel by restoring the normal hepatic architecture.</p>

Item Type: Article
Uncontrolled Keywords: Punica granatum reactive oxygen species antioxidant activity lipid peroxidation SOD peroxidase catalase
Subjects: 600 Technology > 08 Food technology > 24 Fruits
600 Technology > 08 Food technology > 32 Antioxidants
Divisions: Human Resource Development
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 12 Dec 2005
Last Modified: 30 Jun 2015 12:31
URI: http://ir.cftri.com/id/eprint/249

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