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Histidine metabolism in experimental protein malnutrition in rats.

Rao, D. R. and Deodhar, A. D. and Hariharan, K. (1965) Histidine metabolism in experimental protein malnutrition in rats. The Biochemical journal, 97 (1). pp. 311-7. ISSN 0264-6021

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1. The activities of the enzymes histidase, urocanase and histidine-pyruvate transaminase were studied in rats under conditions of protein malnutrition. Urocanase and histidase activities in liver were markedly lowered in experimental protein malnutrition, but the activity of histidine-pyruvate transaminase was unaffected. There is a metabolic control in vivo of the enzymes involved in the catabolism of histidine. 2. Significant changes in the urinary excretion of histidine, composition of liver and serum were apparent in the protein-malnourished rat. 3. The changes in the activities of the enzymes and other parameters were of a reversible nature and dependent on the nature of the dietary protein. 4. The significance of these findings is discussed in relation to abnormal histidine metabolism in kwashiorkor.

Item Type: Article
Uncontrolled Keywords: metabolism of histidine, protein malnutrition, kwashiorkor, enzymes histidase
Subjects: 600 Technology > 01 Medical sciences > 11 Malnutrition
600 Technology > 08 Food technology > 16 Nutritive value > 05 Enzymes
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 23 Jul 2013 05:01
Last Modified: 23 Jul 2013 05:01
URI: http://ir.cftri.com/id/eprint/2387

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