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Cardiotoxic effects of dichlorvos (DDVP) in albino rats.

Naidu, K. A. and Viswanatha, S. and Krishnakumari, M. K. (1987) Cardiotoxic effects of dichlorvos (DDVP) in albino rats. Indian Journal of Physiology and Pharmacology, 31 (1). pp. 19-24. ISSN 0019-5499

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Dichlorvos (O, O-dimethyl O-(2,2-dichlorovinyl phosphate: DDVP 76.6 X EC) an organophosphate pesticide had a profound effect on cardiac activity of albino rats. Adult male rats anesthetized with pentobarbitone were administered 30, 50, 70 and 90 mg/kg body weight of dichlorvos. The heart rate and electrocardiogram were monitored and acetylcholinesterase activity was measured in heart and brain. Dichlorvos produced abnormalities in ECG, decrease in heart rate, cardiac arrest and inhibition of cholinesterase activity. It is suggested that cardiotoxic effect of DDVP may be mediated by the accumulated acetylcholine as a result of cholinesterase inhibition.

Item Type: Article
Uncontrolled Keywords: dichlorvos, cardiotoxic effect
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 26 Pesticide Chemistry
600 Technology > 01 Medical sciences > 17 Toxicology
Divisions: Dept. of Biochemistry
Food Protectants and Infestation Control
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 13 Apr 2018 07:04
Last Modified: 13 Apr 2018 07:04
URI: http://ir.cftri.com/id/eprint/2382

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