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Metalaxyl-induced bradycardia in rats: mediated by alpha-adrenoreceptors.

Naidu, K. A. and Radhakrishnamurty, R. (1988) Metalaxyl-induced bradycardia in rats: mediated by alpha-adrenoreceptors. Journal of Toxicology and Environmental Health, 23 (4). pp. 495-8. ISSN 0098-4108

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Abstract

The effect of the fungicide metalaxyl [methyl N-(2-methoxyacetyl)-N-(2,6-xylyl)-DL-alaniate] on cardiac activity was investigated in albino rats anesthetized with phentobarbitone. Metalaxyl caused dose-dependent bradycardia, and at higher doses (250 and 300 mg/kg body weight) the sustained bradycardia led to cardiac arrest. The acetylcholinesterase activities in brain and heart were not affected in metalaxyl-treated rats. However, the bradycardia induced by the fungicide was blocked by pretreatment of rats with the alpha-adrenoreceptor antagonist phentolamine (20 mg/kg, ip). The data suggest that the bradycardia-inducing effect of metalaxyl was not mediated by the cholinergic system but through alpha-adrenoreceptors.

Item Type: Article
Uncontrolled Keywords: fungicide, metalaxyl, cardiac activity
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 26 Pesticide Chemistry
600 Technology > 01 Medical sciences > 17 Toxicology
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 09 Apr 2018 04:06
Last Modified: 09 Apr 2018 04:06
URI: http://ir.cftri.com/id/eprint/2377

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