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Dermal toxicity of Fusarium toxins in combinations.

Bhavanishankar, T. N. and Ramesh, H. P. and Shantha, T. (1988) Dermal toxicity of Fusarium toxins in combinations. Archives of Toxicology, 61 (3). pp. 241-4. ISSN 0340-5761

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T 2 toxin (T 2), diacetoxyscirpenol (DAS), fusarenon X (FX) and butenolide (Bd) at concentrations of 0.2, 0.3, 5 and 10 micrograms/site, respectively, were applied individually and in combinations on shaved skin of guinea pigs. Erythema and induration were observed on skin patches treated with the toxins. Increase in the thickness of stratum malpighii was the major histological change observed. Mild to moderate degeneration of fibrocytes and cellular infiltration were found in the corium of skin treated with FX, Bd, DAS and T 2. The order of toxicity of individual toxins was T 2 greater than DAS greater than FX greater than Bd. Combinations of T 2 + FX and T 2 + Bd resulted in antagonism, while DAS + FX and DAS + Bd caused synergism.

Item Type: Article
Uncontrolled Keywords: T 2 toxin - Diacetoxyscirpenol - Fusarenon X - Butenolide - Fusarium toxins - Dermal toxicity - Combined toxicity
Subjects: 600 Technology > 01 Medical sciences > 17 Toxicology
600 Technology > 08 Food technology > 16 Nutritive value > 08 Grains
Divisions: Food Microbiology
Food Safety Analytical Quality Control Lab
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 20 Mar 2018 06:53
Last Modified: 20 Mar 2018 06:53
URI: http://ir.cftri.com/id/eprint/2373

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