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Toxicity of pirimiphos-methyl: I. The acute and subacute oral toxicity in albino rats.

Rajini, P. S. and Krishnakumari, M. K. (1988) Toxicity of pirimiphos-methyl: I. The acute and subacute oral toxicity in albino rats. Journal of Environmental Science and Health. Part. B, Pesticides, food contaminants, and agricultural wastes, 23 (2). pp. 127-44. ISSN 0360-1234

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Abstract

In an acute study, albino rats of both sexes were orally administered graded doses of Pirimiphosmethyl, and the statistically computed median lethal dose (LD-50) were 1861 and 1667 mg/kg body weight for male and female rats respectively. No treatment related changes were discernible with regard to food intake, growth, gross or histopathology of the organs. In a time-course study, the correlation between symptoms and degree of esterase inhibition was examined in rats administered the minimum lethal dose (MLD: 1000 mg/kg b.w.) of the insecticide. Time-course inhibition pattern of both cholinesterase (ChE) and non-specific carboxylesterase (NSE) activities in brain and plasma revealed maximum inhibition at 24 h post-treatment which correlated well with the intensity of symptoms. In a subacute study, groups of male rats were fed dietary Pirimiphos-methyl at 0, 10, 250, 500 and 1000 ppm for 28 days. Food consumption and growth rate were not affected throughout the experimental period. At necropsy after 28 days, no gross pathological changes were seen in any of the organs except a slight increase in liver weight at 1000 ppm. Though no statistical differences were observed in the levels of hepatic transaminases, a significant increase in serum transaminase was evident. Significant increase in the activities of hepatic ALP, beta-GLR and serum ALP were evident at 500 and 1000 ppm. Further, significant inhibition of plasma PChE was evident at 250, 500 and 1000 ppm while the degree of inhibition of brain AChE was significant only at the higher dosages. No histopathological alterations were observed in any of the organs.

Item Type: Article
Uncontrolled Keywords: Pirimiphos-methyl, LD-50, Cholinesterase, non-specific carboxylesterase, time-course inhibition, serum and hepatic enzymes
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 26 Pesticide Chemistry
600 Technology > 01 Medical sciences > 17 Toxicology
Divisions: Food Protectants and Infestation Control
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 20 Mar 2018 06:49
Last Modified: 20 Mar 2018 06:49
URI: http://ir.cftri.com/id/eprint/2371

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