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Biochemical changes produced by beta- and gamma-hexachlorocyclohexane isomers in albino rats.

Srinivasan, K. and Radhakrishnamurty, R. (1988) Biochemical changes produced by beta- and gamma-hexachlorocyclohexane isomers in albino rats. Journal of Environmental Science and Health. Part. B, Pesticides, food contaminants, and agricultural wastes, 23 (4). pp. 367-86. ISSN 0360-1234

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Abstract

Administration of beta- and gamma-isomers of hexachlorocyclohexane (HCH) at 800 ppm dietary level for 2 weeks to albino rats produced noticeable hepatocellular damage as indicated by elevations in serum aminotransferases and decreases in hepatic soluble enzymes. Although serum total LDH activity was not altered, the LD5 isoenzyme was proportionately higher in the HCH isomers treated animals. Treatment of rats with beta- and gamma-isomers of HCH increased the hepatic glucose-6-phosphate dehydrogenase and aldolase activities suggesting a higher rate of glucose oxidation. Liver glucose-6-phosphatase activity was decreased in these animals indicating inactivation of gluconeogenesis in liver. Dietary beta- and gamma-HCH decreased the liver mitochondrial DNP/Mg++/Ca++-activated ATPases thus affecting the energy metabolism. An unaltered ratio of DNP/Mg++-ATPase, a study of swelling pattern of hepatic mitochondria, and NAD+ permeability test suggested the maintenance of structural integrity of mitochondrial membrane in these pesticide fed animals. Liver microsomal Na+,K+-ATPases were lower in these animals.

Item Type: Article
Uncontrolled Keywords: hexachlorocyclohexane, tissue enzyme changes, hepatotoxicity
Subjects: 500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 07 Enzyme Biochemistry
600 Technology > 01 Medical sciences > 17 Toxicology
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 20 Mar 2018 06:34
Last Modified: 20 Mar 2018 06:34
URI: http://ir.cftri.com/id/eprint/2368

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