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Effect of metalaxyl on heart rate in rats: role of alpha 1-adrenoreceptors.

Naidu, K. A. and Radhakrishnamurty, R. (1989) Effect of metalaxyl on heart rate in rats: role of alpha 1-adrenoreceptors. Journal of Toxicology and Environmental Health, 26 (2). pp. 203-7. ISSN 0098-4108

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Abstract

Intraperitoneal injection of metalaxyl (250 mg/kg) produced a decrease in heart rate lasting for more than 60 min in anesthetized rats. Pretreatment of rats with phentolamine (a nonselective alpha-adrenoreceptor antagonist, ip at 20 mg/kg) and prazosin (an alpha 1-adrenoreceptor antagonist, ip at 5 mg/kg) significantly reduced the bradycardia induced by metalaxyl. Yohimbine (an alpha 2-adrenoreceptor antagonist, ip at 10 mg/kg) did not change the effect of metalaxyl on heart rate. The results suggest that alpha 2-adrenoreceptors mediate the bradycardic effect of metalaxyl.

Item Type: Article
Uncontrolled Keywords: metalaxyl, heart rate, adrenoreceptors
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 26 Pesticide Chemistry
600 Technology > 01 Medical sciences > 17 Toxicology
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 20 Mar 2018 08:19
Last Modified: 20 Mar 2018 08:19
URI: http://ir.cftri.com/id/eprint/2363

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