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Inhibition of monoamine oxidase by the fungicide metalaxyl.

Naidu, K. A. (1989) Inhibition of monoamine oxidase by the fungicide metalaxyl. Journal of Toxicology and Environmental Health, 27 (3). pp. 395-8. ISSN 0098-4108

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Abstract

The in vitro effect of metalaxyl on monoamine oxidase (MAO) activity in rat heart was studied. Metalaxyl decreased MAO activity in a dose-dependent manner. The inhibitory concentration (IC50) for metalaxyl was found to be 19 mumol. Substrate-dependent kinetic studies demonstrated noncompetitive inhibition as evidenced by decreased velocity of enzyme activity (Vmax) without significant change in enzyme-substrate affinity (Km). The inhibition of MAO activity by metalaxyl suggests interference with amine metabolism.

Item Type: Article
Uncontrolled Keywords: metalaxyl, monoamine oxidase, fungicide
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 26 Pesticide Chemistry
600 Technology > 01 Medical sciences > 17 Toxicology
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 20 Mar 2018 08:09
Last Modified: 20 Mar 2018 08:09
URI: http://ir.cftri.com/id/eprint/2360

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