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Inhibitory pattern of tissue esterases in rats fed dietary pirimiphos-methyl.

Rajini, P. S. and Muralidhara, Dr. and Krishnakumari, M. K. (1989) Inhibitory pattern of tissue esterases in rats fed dietary pirimiphos-methyl. Journal of Evironmental Science and Health. Part. B, Pesticides, food contaminants, and agricultural wastes, 24 (5). pp. 509-24. ISSN 0360-1234

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Activities of Acetylcholinesterase (AChE) in brain and erythrocytes, pseudocholinesterase (PChE) in plasma and non-specific carboxylesterase (NSE) in brain, liver, plasma and kidney were assayed at weekly intervals in growing male rats fed dietary pirimiphos-methyl at dosages of 1000, and 1500 ppm for a period of 28 days. Significant inhibition of tissue esterases were observed at the end of 7 days at both the dosages and the enzyme activities remained markedly inhibited at subsequent intervals. Activities of all enzymes (excepting Brain AChE) returned to normal levels following a 7-day maintenance on the insecticide-free diet implicating that pirimiphos-methyl induced little or no permanent tissue damage. The results suggest that plasma NSE level may also serve as a sensitive indicator in monitoring OPI exposure.

Item Type: Article
Uncontrolled Keywords: Pirimiphos-methyl, dietary, Acetyl cholinesterase, Non-specific carboxyl esterase, inhibition, recovery
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 26 Pesticide Chemistry
600 Technology > 01 Medical sciences > 17 Toxicology
Divisions: Dept. of Biochemistry
Food Protectants and Infestation Control
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 20 Mar 2018 08:34
Last Modified: 20 Mar 2018 08:34
URI: http://ir.cftri.com/id/eprint/2354

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