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Effect of vitamin A on hexachlorocyclohexane (HCH) toxicity in the rat.

Joseph, P. and Shivanandappa, T. and Narasimhamurthy, K. and Krishnakumari, M. K. (1992) Effect of vitamin A on hexachlorocyclohexane (HCH) toxicity in the rat. General Pharmacology, 23 (6). pp. 1159-64. ISSN 0306-3623

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1. Technical hexachlorocyclohexane (HCH) depleted hepatic stores of vitamin A in male albino rats to cause secondary vitamin A deficiency. 2. Toxicity of HCH in rats is augmented by dietary vitamin A-deficiency as evidenced by growth retardation, organ hypertrophies and alterations in the serum and liver levels of the marker enzymes of toxicity. 3. Supplementation of dietary vitamin A to the rats either in adequate (2000 IU/kg diet) or in an excess but not hypervitaminotic level (10(5) IU/kg diet) resulted in significant protection against the toxicity of HCH. 4. The activities of the hepatic xenobiotic metabolizing enzymes were generally low (with the exception of glutathione S-transferase) in the vitamin A-deficient rats compared to those of the vitamin A supplemented diet groups. 5. The results indicated that dietary vitamin A influences the response of male albino rats to HCH toxicity possibly by modulating the activities of hepatic xenobiotic metabolizing enzymes.

Item Type: Article
Uncontrolled Keywords: Vitamin A,hexachlorocyclohexane, Toxicity
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 26 Pesticide Chemistry
600 Technology > 01 Medical sciences > 17 Toxicology
600 Technology > 08 Food technology > 16 Nutritive value > 04 Vitamins
Divisions: Dept. of Biochemistry
Food Protectants and Infestation Control
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 21 Mar 2018 07:05
Last Modified: 21 Mar 2018 07:05
URI: http://ir.cftri.com/id/eprint/2305

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