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Inhibition of monoamine oxidase-A of rat brain by pyrethroids--an in vitro kinetic study.

Rao, G. V. and Rao, K. S. J. (1993) Inhibition of monoamine oxidase-A of rat brain by pyrethroids--an in vitro kinetic study. Molecular and Cellular Biochemistry, 124 (2). pp. 107-14. ISSN 0300-8177

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Abstract

An in vitro kinetic study on inhibition of the monoamine oxidase-A (MAO-A) of the rat brain by two pyrethroids, namely permethrin (PM) and cypermethrin (CPM), has shown that PM and CPM competitively inhibit MAO-A by altering both the Michaelis-Menten constant (Km) and the maximum velocity (Vmax). Inhibitor constant values (Ki) indicated that CPM was a more effective inhibitor of MAO-A than PM. Both PM and CPM caused maximum inhibition of MAO-A at neutral pH. CPM significantly elevated the activation energy values of MAO-A as compared to those of PM.

Item Type: Article
Uncontrolled Keywords: permethrin, cypermethrin, monoamine oxidase-A
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 26 Pesticide Chemistry
600 Technology > 01 Medical sciences > 17 Toxicology
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 21 Mar 2018 08:25
Last Modified: 21 Mar 2018 08:25
URI: http://ir.cftri.com/id/eprint/2287

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