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Effect of curcumin and eugenol on iron-induced hepatic toxicity in rats.

Reddy, A. C. P. and Lokesh, B. R. (1996) Effect of curcumin and eugenol on iron-induced hepatic toxicity in rats. Toxicology, 107 (1). pp. 39-45. ISSN 0300-483X

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Abstract

Male Wistar rats injected i.p. with 30 mg Fe2+/kg body weight show hepatic damage as measured by an increase in lipid peroxides which correlated with elevated serum enzymes, alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT) and lactate dehydrogenase (LDH). Oral administration of spice principles, curcumin from turmeric (30 mg/kg body weight) or eugenol from cloves (100 mg/kg body weight), for 10 days lowered the liver and serum lipid peroxide levels, serum ALAT, ASAT and LDH, enhanced by i.p. injection of iron. This study indicates that curcumin or eugenol reduces the iron-induced hepatic damage by lowering lipid peroxidation.

Item Type: Article
Uncontrolled Keywords: Iron; Hepatic toxicity; Lipid peroxidation; Curcumin and eugenol
Subjects: 600 Technology > 01 Medical sciences > 17 Toxicology
600 Technology > 08 Food technology > 30 Spices/Condiments
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 22 Mar 2018 05:20
Last Modified: 22 Mar 2018 05:20
URI: http://ir.cftri.com/id/eprint/2242

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