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Presence of an acidic glycoprotein in the serum of arthritic rats: modulation by capsaicin and curcumin.

Joe, B and Prasada Rao, U. J. S. and Lokesh, B. R. (1997) Presence of an acidic glycoprotein in the serum of arthritic rats: modulation by capsaicin and curcumin. Molecular and Cellular Biochemistry, 169 (1-2). pp. 125-34. ISSN 0300-8177

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Abstract

Levels of various serum proteins were found to change in adjuvant induced arthritis. Increased levels of a glycoprotein with an apparent molecular weight of 72 kDa (Gp A72) were observed in the sera of arthritic rats. Gp A72 is an acidic glycoprotein with a pI of 5.1. Gp A72 also showed antitryptic activity. The appearance of Gp A72 in the serum preceded the onset of paw inflammation in arthritic rats and persisted in the chronic phase. Oral administration of the antiinflammatory spice principles-capsaicin (from red pepper) and curcumin (from turmeric) lowered the levels of Gp A72 by 88 and 73% respectively with concomitant lowering of paw inflammation in arthritic rats.

Item Type: Article
Uncontrolled Keywords: serum acidic glycoprotein, arthritis, capsaicin, curcumin
Subjects: 500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 16 Protein Biochemistry
600 Technology > 08 Food technology > 30 Spices/Condiments
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 02 Jul 2009 09:38
Last Modified: 01 Oct 2018 09:28
URI: http://ir.cftri.com/id/eprint/2220

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